A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress–damage response

dc.contributor.author Bustos, Patricia L.
dc.contributor.author Volta, Viviana J.
dc.contributor.author Perrone, Alina E
dc.contributor.author Milduberger, Natalia A.
dc.contributor.author Bua, Jaqueline
dc.date.accessioned 2023-10-03T18:30:38Z
dc.date.available 2023-10-03T18:30:38Z
dc.date.issued 2017-2-6
dc.description.abstract Mitochondria have an important role in energy production, homeostasis and cell death. The opening of the mitochondrial permeability transition pore (mPTP) is considered one of the key events in apoptosis and necrosis, modulated by cyclophilin D (CyPD), a crucial component of this protein complex. In Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, we have previously described that mitochondrial permeability transition occurs after oxidative stress induction in a cyclosporin A-dependent manner, a well-known cyclophilin inhibitor. In the present work, a mitochondrial parasite cyclophilin, named TcCyP22, which is homolog to the mammalian CyPD was identified. TcCyP22-overexpressing parasites showed an enhanced loss of mitochondrial membrane potential and loss of cell viability when exposed to a hydrogen peroxide stimulus compared with control parasites. Our results describe for the first time in a protozoan parasite that a mitochondrial cyclophilin is a component of the permeability transition pore and is involved in regulated cell death induced by oxidative stress
dc.identifier.citation Bustos, P. L.; Volta, B.J.; Perrone, A.E.; Milduberger, N.; Bua, J.(2017). A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress–damage response. In: Cell Death Discovery 3:16092.
dc.identifier.other https://doi.org/10.1038/cddiscovery.2016.92
dc.identifier.uri https://repositorio.uai.edu.ar/handle/123456789/1817
dc.language.iso en
dc.publisher Cell Death Differentiation Association (ADMC)
dc.subject Trypanosoma cruzi
dc.subject Chagas disease
dc.subject protozoan parasite
dc.subject mitochondrial cyclophilin
dc.title A homolog of cyclophilin D is expressed in Trypanosoma cruzi and is involved in the oxidative stress–damage response
dc.type ARTICULO
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