Trypanosoma cruzi infection at the maternal-fetal interface : implications of parasite load in the congenital transmission and challenges in the diagnosis of infected newborns

dc.contributor.author Bustos, Patricia L.
dc.contributor.author Milduberger, Natalia A.
dc.contributor.author Volta, Viviana J.
dc.contributor.author Perrone, Alina E
dc.contributor.author Laucella, Susana A.
dc.contributor.author Bua, Jacqueline
dc.date.accessioned 2023-10-03T18:31:21Z
dc.date.available 2023-10-03T18:31:21Z
dc.date.issued 2019-6-7
dc.description.abstract Trypanosoma cruzi is the protozoan unicellular parasite that causes Chagas disease. It can be transmitted from infected mothers to their babies via the connatal route, thus being able to perpetuate even in the absence of Triatomine insect vectors. Chagas disease was originally endemic in Central and South America, but migration of infected women of childbearing age has spread the T. cruzi congenital infection to non-endemic areas like North America, Europe, Japan, and Australia. Currently, 7 million people are affected by this infection worldwide. This review focuses on the relevance of the T. cruzi parasite levels in different aspects of the congenital T. cruzi infection such as the mother-to-child transmission rate, the maternal and fetal immune response, and its impact on the diagnosis of infected newborns. Improvements in detection of this parasite, with tools that can be easily adapted to be used in remote rural areas, will make the early diagnosis of infected children possible, allowing a prompt trypanocidal treatment and avoiding the current loss of opportunities for the diagnosis of 100% of T. cruzi congenitally infected infants
dc.identifier.citation Bustos, P.L.; Milduberger, N.; Volta, B.J.; Perrone, A.E.; Laucella, S.A.; Bua, J. (2019). Trypanosoma cruzi infection at the maternal-fetal interface : implications of parasite load in the congenital transmission and challenges in the diagnosis of infected newborns. In: Frontiers in Microbiology 10:1250
dc.identifier.other 10.3389/fmicb.2019.01250
dc.identifier.uri https://repositorio.uai.edu.ar/handle/123456789/1821
dc.language.iso en
dc.publisher Frontiers
dc.subject Trypanosoma cruzi
dc.subject mother-to-child transmission
dc.subject parasitemia
dc.subject infected pregnant women
dc.subject congenitally infected infants
dc.subject early diagnosis
dc.title Trypanosoma cruzi infection at the maternal-fetal interface : implications of parasite load in the congenital transmission and challenges in the diagnosis of infected newborns
dc.type ARTICULO
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