A functional analysis of the cyclophilin repertoire in the protozoan parasite Trypanosoma cruzi

dc.contributor.author Fuchs, Alicia Graciela
dc.contributor.author Perrone, Alina E
dc.contributor.author Milduberger, Natalia A.
dc.contributor.author Bustos, Patricia L.
dc.contributor.author Bua, Jaqueline
dc.date.accessioned 2023-09-27T19:48:07Z
dc.date.available 2023-09-27T19:48:07Z
dc.date.issued 2018-10-31
dc.description.abstract Trypanosoma cruzi is the etiological agent of Chagas disease. It affects eight million people worldwide and can be spread by several routes, such as vectorborne transmission in endemic areas and congenitally, and is also important in non-endemic regions such as the United States and Europe due to migration from Latin America. Cyclophilins (CyPs) are proteins with enzymatic peptidyl-prolyl isomerase activity (PPIase), essential for protein folding in vivo. Cyclosporin A (CsA) has a high binding affinity for CyPs and inhibits their PPIase activity. CsA has proved to be a parasiticidal drug on some protozoa, including T. cruzi. In this review, we describe the T. cruzi cyclophilin gene family, that comprises 15 paralogues. Among the proteins isolated by CsA-affinity chromatography, we found orthologues of mammalian CyPs. TcCyP19, as the human CyPA, is secreted to the extracellular environment by all parasite stages and could be part of a complex interplay involving the parasite and the host cell. TcCyP22, an orthologue of mitochondrial CyPD, is involved in the regulation of parasite cell death. Our findings on T. cruzi cyclophilins will allow further characterization of these processes, leading to new insights into the biology, the evolution of metabolic pathways, and novel targets for anti-T. cruzi contro
dc.identifier.citation Perrone, A.E.; Milduberger, N.; Fuchs, A.G.; Bustos, P.L.; Bua, J. (2018). A functional analysis of the cyclophilin repertoire in the protozoan parasite Trypanosoma cruzi. In: Biomolecules 8(4):132
dc.identifier.other 10.3390/biom8040132
dc.identifier.uri https://repositorio.uai.edu.ar/handle/123456789/1753
dc.language.iso en
dc.publisher MDPI
dc.subject Trypanosoma cruzi
dc.subject Chagas disease
dc.subject protozoan parasite
dc.subject cyclosporin A
dc.subject non-immunosuppressive analogs
dc.subject trypanocidal compounds
dc.subject cell death
dc.subject cyclophilins
dc.subject TcCyP19
dc.subject TcCyP22
dc.title A functional analysis of the cyclophilin repertoire in the protozoan parasite Trypanosoma cruzi
dc.type ARTICULO
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